In this work we present new scalable, information theory-based variational methods for the efficient model reduction of high-dimensional reaction networks. The proposed methodology combines, (a) information theoretic tools for sensitivity analysis that allow us to identify the proper coarse variables of the reaction network, with (b) variational approximate inference methods for training a best-fit reduced model. The overall approach takes advantage of both physicochemical modeling and data-based approaches and allows to construct optimal parameterized reduced dynamics in the number of species, reactions and parameters, while controlling the information loss due to the reduction. We demonstrate the effectiveness of our model reduction method on several complex, high-dimensional biochemical reaction networks from the recent literature. 查看全文>>