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Modeling Oral Multispecies Biofilm Recovery After Antibacterial Treatment. (arXiv:1810.08887v1 [q-bio.QM])
来源于:arXiv
Recovery of multispecies oral biofilms is investigated following treatment by
chlorhexidine gluconate (CHX), iodine-potassium iodide (IPI) and Sodium
hypochlorite (NaOCl) both experimentally and theoretically. Experimentally,
biofilms taken from two donors were exposed to the three antibacterial
solutions (irrigants) for 10 minutes, respectively. We observe that (a) live
bacterial cell ratios decline for a week after the exposure and the trend
reverses beyond a week; after fifteen weeks, live bacterial cell ratios in
biofilms fully return to their pretreatment levels; (b) NaOCl is shown as the
strongest antibacterial agent for the oral biofilms; (c) multispecies oral
biofilms from different donors showed no difference in their susceptibility to
all the bacterial solutions. Guided by the experiment, a mathematical model for
biofilm dynamics is developed, accounting for multiple bacterial phenotypes,
quorum sensing, and growth factor proteins, to describe the nonlinear time
evolutionary 查看全文>>