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Global properties of an age-structured virus model with saturated antibody immune response, multi-target cells and general incidence rate. (arXiv:1712.05064v1 [math.DS])
来源于:arXiv
Some viruses, such as human immunodeficiency virus, can infect several types
of cell populations. The age of infection can also affect the dynamics of
infected cells and production of viral particles. In this work, we study a
virus model with infection-age and different types of target cells which takes
into account the saturation effect in antibody immune response and a general
non-linear infection rate. We construct suitable Lyapunov functionals to show
that the global dynamics of the model is completely determined by two critical
values: the basic reproduction number of virus and the reproductive number of
antibody response. 查看全文>>