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Increased accuracy of planning tools for optimization of dynamic multileaf collimator delivery of radiotherapy through reformulated objective functions. (arXiv:1802.00619v1 [math.OC])
来源于:arXiv
The purpose of this study is to examine in a clinical setting a novel
formulation of objective functions for intensity-modulated radiotherapy (IMRT)
treatment plan multicriteria optimization (MCO) that we suggested in a recent
study. The proposed objective functions are extended with dynamic multileaf
collimator (DMLC) delivery constraints from the literature, and a tailored
interior-point method is described to efficiently solve the resulting
optimization formulation. In a numerical planning study involving three patient
cases, DMLC plans Pareto optimal to the MCO formulation with the proposed
objective functions are generated. Evaluated based on pre-defined plan quality
indices, these DMLC plans are compared to conventionally generated DMLC plans.
Comparable plan quality is observed. Supported by these results, the proposed
objective functions are argued to have a potential to streamline the planning
process, since they are designed to overcome the methodological shortcomings
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